… Pyridinyl imidazole compounds that have the ability to inhibit p38 MAP kinase and block
proinflammatory cytokine production have been named cytokinesuppressive antiinflammatory …

… cytokines would be an ideal therapeutic agent for rheumatoid arthritis. This, along with other
therapeutic … as one of the most validated therapeutic targets for rheumatoid arthritis. The …

… family of RTKs regulates an intriguing mix of processes, including cell proliferation/survival,
cell adhesion and migration, blood clot stabilization, and regulation of inflammatory cytokine …

… Cytokines are the soluble mediators of immune activation, altered fibroblast proliferation …
provide important therapeutic targets. In the present review, the involvement of cytokines in SSc …

… many molecules that might serve as novel therapeutic targets for a wide range of … therapeutic
manipulations, including regulation of glutamate, reactive oxygen species, and cytokines…

… Thus, understanding which cytokines play a pivotal role in the disease process can suggest
potential therapeutic targets. A number of cytokines have been therapeutically targeted with …

… therapy targeted towards the molecular and cellular pathways. This article reviews cytokine
biology … on immunopathology of the disease, therapeutic targeting and the way that current or …

… In the present review, we examined the roles of circulating cytokines and cytokines in CSF
… such cytokines as therapeutic targets. It has been well documented that circulating cytokines …

… be associated with the induction and activity of the disease, is included the BAFF, which is
contemplated as one of the therapeutic targets for the modulation of the disease.48, 49, 50, 51 …

… We hypothesize that IL-4 and IL-13 may constitute potential therapeutic targets as they
represent two of the main mediators of type 2 responses and pro-fibrotic activity, that play an …