[HTML][HTML] Biologics for targeting inflammatory cytokines, clinical uses, and limitations
P Rider, Y Carmi, I Cohen - International journal of cell biology, 2016 - hindawi.com
… of cytokines as therapeutic targets are as follows: (i) unlike in chemical drugs, specific protein
which mediate the inflammatory process can be inhibited; (ii) cytokines … these cytokines are …
which mediate the inflammatory process can be inhibited; (ii) cytokines … these cytokines are …
Alcoholic liver disease: pathogenesis and new therapeutic targets
B Gao, R Bataller - Gastroenterology, 2011 - Elsevier
… The identification of therapeutic targets for ALD has been … we can test the effects of targeting
factors found to be involved in … identify therapeutic targets because serum levels of cytokines …
factors found to be involved in … identify therapeutic targets because serum levels of cytokines …
Immune regulation of skin wound healing: mechanisms and novel therapeutic targets
J Larouche, S Sheoran, K Maruyama… - Advances in wound …, 2018 - liebertpub.com
… targeted to promote chronic wound repair or skin regeneration and several growth factors,
cytokines, … However, no cytokine-based, chronic wound therapies have reached clinical trials; …
cytokines, … However, no cytokine-based, chronic wound therapies have reached clinical trials; …
Targeting the “cytokine storm” for therapeutic benefit
RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… , do trigger life-threatening “cytokine storms” in the host which can … cytokine storms which
may prove useful in the clinic in the future and compare them to more traditional therapeutic …
may prove useful in the clinic in the future and compare them to more traditional therapeutic …
Pancreatic cancer stroma: an update on therapeutic targeting strategies
… our current understanding of the three principal constituents of PDAC stroma, their effect on
the prevalent immune landscape and promising therapeutic targets within this compartment. …
the prevalent immune landscape and promising therapeutic targets within this compartment. …
Cytokines as potential novel therapeutic targets in severe inflammatory cardiomyopathy
P Suwalski, A Golpour, J Weiner III, N Musigk, F Balzer… - medRxiv, 2023 - medrxiv.org
… Finally, to evaluate for potential causality of the discovered cytokines, we evaluated if already
existing therapeutic inhibitors of our cytokines of interest have a potential cardioprotective …
existing therapeutic inhibitors of our cytokines of interest have a potential cardioprotective …
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets
AM Gressner, R Weiskirchen - Journal of cellular and molecular …, 2006 - Wiley Online Library
… Although the cellular responses to this cytokine are complex, the signalling pathways of this
pivotal cytokine during the fibrogenic response and its connection to other signal cascades …
pivotal cytokine during the fibrogenic response and its connection to other signal cascades …
Cytokines: names and numbers you should care about
SR Holdsworth, PY Gan - Clinical journal of the American Society …, 2015 - journals.lww.com
… Although it is likely that cytokines are therapeutic targets in this disease, the known presence
of multiple immunoregulatory abnormalities suggests that SLE should not be considered as …
of multiple immunoregulatory abnormalities suggests that SLE should not be considered as …
[HTML][HTML] Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses
MB Orr, JC Gensel - Neurotherapeutics, 2018 - Elsevier
… therapies. Infiltrating neutrophils and monocytes are recruited to the injury site through glial
chemokine and cytokine … properties and are targeted for therapeutic modification. Here, we …
chemokine and cytokine … properties and are targeted for therapeutic modification. Here, we …
Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy
T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
… for cancer therapy, inflammatory cytokines are the most efficient targets. In this … cytokines.
We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for …
We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for …