Three-component reactions of isocyanoacetates, amines and 3-formylchromones initiated by an unexpected aza-Michael addition
We present herein a new mode of three-component reactions between isocyanoacetates,
amines and 3-formylchromones. Both experimental and DFT studies revealed that this Ag-
catalyzed unusual transformation is initiated by a facile aza-Michael addition instead of the
conventional imine condensation. This catalytic method enables an efficient synthesis of
polysubstituted pyrroles.
amines and 3-formylchromones. Both experimental and DFT studies revealed that this Ag-
catalyzed unusual transformation is initiated by a facile aza-Michael addition instead of the
conventional imine condensation. This catalytic method enables an efficient synthesis of
polysubstituted pyrroles.
We present herein a new mode of three-component reactions between isocyanoacetates, amines and 3-formylchromones. Both experimental and DFT studies revealed that this Ag-catalyzed unusual transformation is initiated by a facile aza-Michael addition instead of the conventional imine condensation. This catalytic method enables an efficient synthesis of polysubstituted pyrroles.
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