Cyclic variations in coronary blood flow (CFVs) in dogs with experimental coronary artery
stenosis and endothelial injury appear to result primarily from the aggregation of platelets at
the site of stenosis followed by dislodgement and distal embolization. Using this canine
model, we tested the hypotheses:(a) that thrombin is an important mediator of CFVs in dogs
with coronary stenoses and endothelial injury;(b) that inhibition of thrombin with heparin, or
MCI-9038, a selective thrombin inhibitor, abolishes CFVs in this model; and (c) that abolition …

Thrombin is an important mediator of platelet aggregation in stenosed canine coronary
arteries with endothelial injury | CiNii Research … Thrombin is an important mediator of
platelet aggregation in stenosed canine coronary arteries with endothelial injury …