Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways
K Kirito, T Watanabe, K Sawada, H Endo… - Journal of Biological …, 2002 - ASBMB
Thrombopoietin (TPO), an essential factor for megakaryopoiesis and thrombopoiesis, works
as a survival factor for megakaryocytic lineage cells. However, little is known about the
molecular mechanism in detail. We show here that TPO supports the survival of TPO-
dependent leukemia cell line UT-7/TPO and normal megakaryocytic progenitors via the
induction of Bcl-xL, an anti-apoptotic member of the Bcl-2 family. We further analyzed the
signal transduction pathways required for TPO-induced Bcl-xL gene expression. A reporter …
as a survival factor for megakaryocytic lineage cells. However, little is known about the
molecular mechanism in detail. We show here that TPO supports the survival of TPO-
dependent leukemia cell line UT-7/TPO and normal megakaryocytic progenitors via the
induction of Bcl-xL, an anti-apoptotic member of the Bcl-2 family. We further analyzed the
signal transduction pathways required for TPO-induced Bcl-xL gene expression. A reporter …
[PDF][PDF] TPO regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol-3-kinase activation pathways
K Kirito, T Watanabe, K Sawada Ki, H Endo, K Ozawa… - J Biol Chem, 2001 - academia.edu
Thrombopoietin (TPO), an essential factor for megakaryopoiesis and thromobopoiesis,
works as a survival factor for megakaryocytic lineage cells. However, little is known about
the molecular mechanism in detail. We show here that TPO supports the survival of TPO-
dependent leukemia cell line UT-7/TPO and normal megakaryocytic progenitors via the
induction of BclxL, an anti-apoptotic member of the Bcl-2 family. We further analyzed the
signal transduction pathways required for TPO-induced Bcl-xL gene expression. A reporter …
works as a survival factor for megakaryocytic lineage cells. However, little is known about
the molecular mechanism in detail. We show here that TPO supports the survival of TPO-
dependent leukemia cell line UT-7/TPO and normal megakaryocytic progenitors via the
induction of BclxL, an anti-apoptotic member of the Bcl-2 family. We further analyzed the
signal transduction pathways required for TPO-induced Bcl-xL gene expression. A reporter …
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