Ticagrelor and aspirin for the prevention of cardiovascular events after coronary artery bypass graft surgery
J Saw, GC Wong, J Mayo, V Bernstein, GBJ Mancini… - Heart, 2016 - heart.bmj.com
Background Ticagrelor was shown to reduce mortality in patients who underwent coronary
artery bypass grafting (CABG), but its effect on graft patency is unknown. Methods We
performed a prospective, randomised, double-blind, placebo-controlled trial, comparing
ticagrelor 90 mg twice daily versus placebo for 3 months added to aspirin 81 mg/day,
following isolated CABG. Aspirin was started within 12 h, and study medication within 72 h
after CABG. Primary outcome was graft occlusion on CT angiography (CTA) performed 3 …
artery bypass grafting (CABG), but its effect on graft patency is unknown. Methods We
performed a prospective, randomised, double-blind, placebo-controlled trial, comparing
ticagrelor 90 mg twice daily versus placebo for 3 months added to aspirin 81 mg/day,
following isolated CABG. Aspirin was started within 12 h, and study medication within 72 h
after CABG. Primary outcome was graft occlusion on CT angiography (CTA) performed 3 …
Ticagrelor and Aspirin for the Prevention of Cardiovascular Events After Coronary Artery Bypass Surgery: The TAP-CABG Study
JWL Saw, G Wong, J Mayo, V Bernstein… - Journal of the American …, 2015 - jacc.org
Background: Ticagrelor reduced mortality by 51% in patients who underwent coronary artery
bypass grafting (CABG) in the PLATO study, but its effect on graft patency is unknown.
Methods: We performed a prospective, randomized, blinded, placebo-controlled trial,
comparing ticagrelor 90mg bid versus placebo for 3 months added to aspirin 81mg/d,
following isolated CABG. Informed consent was obtained prior to CABG, and those who
survived surgery with no contraindication post-CABG to aspirin or ticagrelor were …
bypass grafting (CABG) in the PLATO study, but its effect on graft patency is unknown.
Methods: We performed a prospective, randomized, blinded, placebo-controlled trial,
comparing ticagrelor 90mg bid versus placebo for 3 months added to aspirin 81mg/d,
following isolated CABG. Informed consent was obtained prior to CABG, and those who
survived surgery with no contraindication post-CABG to aspirin or ticagrelor were …