Tissue Engineering: Engineering Silk Fibroin‐Based Nerve Conduit with Neurotrophic Factors for Proximal Protection after Peripheral Nerve Injury (Adv. Healthcare …

CR Carvalho, W Chang, J Silva‐Correia… - Advanced …, 2021 - Wiley Online Library
Advanced Healthcare Materials, 2021Wiley Online Library
The incorporation and delivery of neurotrophic factors that stimulate nerve repair in
previously developed tunable enzymatically crosslinked silk fibroin-based conduits are
presented. In article number 2000753 by Joaquim M. Oliveira and co-workers, glial cell line-
derived neurotrophic factor (GDNF), acting upon motor and sensory neurons, also
instigating angiogenesis, uses these conduits as a platform for its controlled delivery,
enhancing motor and sensory regeneration both in vivo and in vitro.
The incorporation and delivery of neurotrophic factors that stimulate nerve repair in previously developed tunable enzymatically crosslinked silk fibroin-based conduits are presented. In article number 2000753 by Joaquim M. Oliveira and co-workers, glial cell line-derived neurotrophic factor (GDNF), acting upon motor and sensory neurons, also instigating angiogenesis, uses these conduits as a platform for its controlled delivery, enhancing motor and sensory regeneration both in vivo and in vitro.
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