The epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two
paramount processes driving tumor progression, therapy resistance, and cancer metastasis.
Recent experiments show that cells with varying EMT and CSC phenotypes are spatially
segregated in the primary tumor. The underlying mechanisms generating such
spatiotemporal dynamics in the tumor microenvironment, however, remain largely
unexplored. Here, we show through a mechanism-based dynamical model that the diffusion …

Abstract The Epithelial-Mesenchymal Transition (EMT) and Cancer Stem Cell (CSC)
formation are two paramount processes driving tumor progression, therapy resistance and
cancer metastasis. Some recent experiments show that cells with varying EMT and CSC
phenotypes are spatially segregated in the primary tumor. The underlying mechanisms
generating such spatiotemporal dynamics and heterogeneity in the tumor micro-
environment, however, remain largely unexplored. Here, we show through a mechanism …