Tracer level radiochemistry to clinical dose preparation of 177Lu-labeled cyclic RGD peptide dimer
Aim Integrin α v β 3 plays a significant role in angiogenesis during tumor growth and
metastasis, and is a receptor for the extracellular matrix proteins with the exposed arginine
(R)-glycine (G)-aspartic acid (D) tripeptide sequence. The over-expression of integrin α v β 3
during tumor growth and metastasis presents an interesting molecular target for both early
detection and treatment of rapidly growing solid tumors. Considering the advantages of 177
Lu for targeted radiotherapy and enhanced tumor targeting capability of cyclic RGD peptide …
metastasis, and is a receptor for the extracellular matrix proteins with the exposed arginine
(R)-glycine (G)-aspartic acid (D) tripeptide sequence. The over-expression of integrin α v β 3
during tumor growth and metastasis presents an interesting molecular target for both early
detection and treatment of rapidly growing solid tumors. Considering the advantages of 177
Lu for targeted radiotherapy and enhanced tumor targeting capability of cyclic RGD peptide …
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