Transcriptional and post-transcriptional regulation of autophagy in the yeast Saccharomyces cerevisiae
E Delorme-Axford, DJ Klionsky - Journal of Biological Chemistry, 2018 - ASBMB
Autophagy is a highly conserved catabolic pathway that is vital for development, cell
survival, and the degradation of dysfunctional organelles and potentially toxic aggregates.
Dysregulation of autophagy is associated with cancer, neurodegeneration, and lysosomal
storage diseases. Accordingly, autophagy is precisely regulated at multiple levels
(transcriptional, post-transcriptional, translational, and post-translational) to prevent aberrant
activity. Various model organisms are used to study autophagy, but the baker's yeast …
survival, and the degradation of dysfunctional organelles and potentially toxic aggregates.
Dysregulation of autophagy is associated with cancer, neurodegeneration, and lysosomal
storage diseases. Accordingly, autophagy is precisely regulated at multiple levels
(transcriptional, post-transcriptional, translational, and post-translational) to prevent aberrant
activity. Various model organisms are used to study autophagy, but the baker's yeast …
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