T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further
characterization of the state of T cells in the CSF in healthy individuals is important for
understanding how T cells provide protective immune surveillance without damaging the
delicate environment of the CNS and providing tissue-specific context for understanding
immune dysfunction in neuroinflammatory disease. Here, we have profiled T cells in the CSF …