Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein
JC Cheng, HM Chang, PCK Leung - Journal of Biological Chemistry, 2013 - ASBMB
Human trophoblast cells express transforming growth factor-β (TGF-β) and TGF-β receptors.
It has been shown that TGF-β1 treatment decreases the invasiveness of trophoblast cells.
However, the molecular mechanisms underlying TGF-β1-decreased trophoblast invasion
are still not fully understood. In the current study, we demonstrated that treatment of HTR-
8/SVneo human trophoblast cells with TGF-β1 decreased cell invasion and down-regulated
the expression of vascular endothelial cadherin (VE-cadherin). In addition, the inhibitory …
It has been shown that TGF-β1 treatment decreases the invasiveness of trophoblast cells.
However, the molecular mechanisms underlying TGF-β1-decreased trophoblast invasion
are still not fully understood. In the current study, we demonstrated that treatment of HTR-
8/SVneo human trophoblast cells with TGF-β1 decreased cell invasion and down-regulated
the expression of vascular endothelial cadherin (VE-cadherin). In addition, the inhibitory …
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