Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells
F Diraison, K Hayward, KL Sanders, F Brozzi, S Lajus… - Diabetologia, 2011 - Springer
Aims/hypothesis This study used proteomics and biochemical approaches to identify novel
glucose-regulated proteins and to unveil their role in pancreatic beta cell function.
Translationally controlled tumour protein (TCTP) was identified to be one such protein, and
further investigations into its function and regulation were carried out. Methods Global
protein profiling of beta cell homogenates following glucose stimulation was performed
using two-dimensional gel electrophoresis. Proteins were identified by mass spectroscopy …
glucose-regulated proteins and to unveil their role in pancreatic beta cell function.
Translationally controlled tumour protein (TCTP) was identified to be one such protein, and
further investigations into its function and regulation were carried out. Methods Global
protein profiling of beta cell homogenates following glucose stimulation was performed
using two-dimensional gel electrophoresis. Proteins were identified by mass spectroscopy …
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