Endoscopic submucosal dissection (ESD) in the esophagus is an expert technique for “en bloc” resection of even widespread mucosal cancers of! 1.5 cm. ESD can provide a quasi-surgical specimen for adequate histopathologic evaluation and significantly reduces the risk of local recurrence compared with conventional widespread endoscopic mucosal resection (“piecemeal” EMR). 1, 2 However, secondary stricture formation is the major drawback for resections! 60% of the esophageal circumference. Multiple dilation sessions may be required, limiting quality of life. Experimental approaches include transplantation of buccal, dermal, or submucosal intestinal cell grafts as well as systemic and local steroid applications. 3–5 However, clinical experience is very limited so far. Since March 2011, we have been performing animal experiments concerning tubular esophageal resection and retransplantation of esophageal and gastric mucosal patches in pigs under an approved protocol with first preliminary but encouraging results when the following clinical case presented.