Background Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse
drug reaction that can lead to devastating thromboembolic complications, including
pulmonary embolism, ischemic limb necrosis necessitating limb amputation, acute
myocardial infarction, and stroke. Methods The methods of this guideline follow the
Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis
Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American …