Triple molecular target approach to selective melanoma cytotoxicity
Organic & Biomolecular Chemistry, 2010•pubs.rsc.org
Phenylalanine-linked pyrrolo [1, 2-a] benzimidazoles were successfully designed to target
melanoma cells in vitro. Our design utilised three molecular targets: a phenylalanine pump,
the reducing enzyme DT-diaphorase, and IMP dehydrogenase. We describe the synthesis of
these compounds as well as the results of in vitro, in vivo, and QSAR studies.
melanoma cells in vitro. Our design utilised three molecular targets: a phenylalanine pump,
the reducing enzyme DT-diaphorase, and IMP dehydrogenase. We describe the synthesis of
these compounds as well as the results of in vitro, in vivo, and QSAR studies.
Phenylalanine-linked pyrrolo[1,2-a]benzimidazoles were successfully designed to target melanoma cells in vitro. Our design utilised three molecular targets: a phenylalanine pump, the reducing enzyme DT-diaphorase, and IMP dehydrogenase. We describe the synthesis of these compounds as well as the results of in vitro, in vivo, and QSAR studies.
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