Abstract The enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases 3 (PFKFB3)
catalyzes the first committed rate-limiting step of glycolysis and is upregulated in cancer
cells. The mechanism of PFKFB3 expression upregulation in cancer cells has not been fully
elucidated. The PFKFB3 3′-UTR is reported to contain AU-rich elements (AREs) that are
important for regulating PFKFB3 mRNA stability. However, the mechanisms by which
PFKFB3 mRNA stability is determined by its 3′-UTR are not well known. We demonstrated …

The enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases 3 (PFKFB3) catalyzes
the first committed rate-limiting step of glycolysis and is upregulated in cancer cells. The
mechanism of PFKFB3 expression upregulation in cancer cells has not been fully
elucidated. The PFKFB3 3'-UTR is reported to contain AU-rich elements (AREs) that are
important for regulating PFKFB3 mRNA stability. However, the mechanisms by which
PFKFB3 mRNA stability is determined by its 3'-UTR are not well known. We demonstrated …