Tumor-derived circulating endothelial cell clusters in colorectal cancer
Clusters of tumor cells are often observed in the blood of cancer patients. These structures
have been described as malignant entities for more than 50 years, although their
comprehensive characterization is lacking. Contrary to current consensus, we demonstrate
that a discrete population of circulating cell clusters isolated from the blood of colorectal
cancer patients are not cancerous but consist of tumor-derived endothelial cells. These
clusters express both epithelial and mesenchymal markers, consistent with previous reports …
have been described as malignant entities for more than 50 years, although their
comprehensive characterization is lacking. Contrary to current consensus, we demonstrate
that a discrete population of circulating cell clusters isolated from the blood of colorectal
cancer patients are not cancerous but consist of tumor-derived endothelial cells. These
clusters express both epithelial and mesenchymal markers, consistent with previous reports …
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