11 天前 - … Tumor infiltrating lymphocytes were analyzed by flow … a CD8 T cell dependent
mechanism. These results provide rationale to launch clinical trials combining DAV132 in cancer …

11 天前 - … of PD-1 + CD8 + tumor infiltrating lymphocytes (TILs) via cis … -specific CD8 + T cells
and stimulated higher expansion … + T cells concomitantly limiting the peripheral CD8 + T cell …

11 天前 - … that CD4 + T cell recognition of MHC-II antigens plays a major role in immunotherapy
responses, including tumor infiltrating lymphocyte (TIL) therapy and cancer vaccines. Most …

11 天前 - … Regulatory T cells (Tregs) are considered potential targets in cancer immunotherapy,
as tumor-infiltrating … One promising way to evoke effective anti-tumor immunity in cancer …

11 天前 - … + T cells in MC38 tumors, but not in B16 tumors. Among the tumor-infiltrating
lymphocytes (TILs) in ERCre mice, there was decreased PD-1/TIM3 expression for CD4 + cells. …

11 天前 - … form a formidable barrier to conventional immunotherapies by various means,
including … signaling with cancer cells, and interactions with tumor-infiltrating lymphocytes. The …

11 天前 - … with decreased tumor-infiltrating T regulatory cells and CD206 … T cells upregulated
ENT1 following activation and … that can be targeted to enhance antitumor T cell responses. …

11 天前 - … T cells than apCAFs from rKPC tumors. apCAFs and CD11c + dendritic cells robustly
activate naïve OT-II CD4 + T cells… cultured with tumor infiltrating CD4 + T cells. Remarkably…

11 天前 - … While limited by sample size, transcriptional changes in the TME indicative of
tumor infiltrating lymphocytes were elevated in on-treatment biopsies for some patients, with …

11 天前 - … of tumor-infiltrating immune cells … T cells at later timepoints in B16F10 tumors.
Conclusions Collectively, our findings uncover VCAM-1 + TAMs as negative regulators of T cells …