Background Regulation of sodium chloride transport in the aldosterone-sensitive distal
nephron is essential for fluid homeostasis and BP control. The chloride-bicarbonate
exchanger pendrin in β-intercalated cells, along with sodium chloride cotransporter (NCC) in
distal convoluted tubules, complementarily regulate sodium chloride handling, which is
controlled by the renin-angiotensin-aldosterone system. Methods Using mice with
mineralocorticoid receptor deletion in intercalated cells, we examined the mechanism and …