Inflammation is typically induced in response to a microbial infection. The release of
proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as
well as recruits adaptive and innate immune effectors to the site of infection. Once the
microbe is cleared, inflammation is resolved by various mechanisms to avoid unnecessary
tissue damage. Autoimmunity arises when aberrant immune responses target self-tissues
causing inflammation. In type 1 diabetes (T1D), T cells attack the insulin producing β cells in …