UPLC–ESI–MS/MS study of the effect of green tea extract on the oral bioavailability of erlotinib and lapatinib in rats: Potential risk of pharmacokinetic interaction
HM Maher, NZ Alzoman, SM Shehata… - … of Chromatography B, 2017 - Elsevier
Green tea (GT) is one of the most consumed beverages worldwide. Tyrosine kinase
inhibitors (TKIs) belong to the oral targeted therapy that gained much interest in oncology
practice, among which are erlotinib (ERL) and lapatinib (LAP). Since green tea polyphenols
(GTP) are known to be inhibitors of receptor tyrosine kinases, GTE could likely potentiate the
anticancer effect of TKIs, but with a possibility of pharmacokinetic (PK) interaction with co-
administered TKIs. In this study, the effect of GTE on the PK of ERL/LAP in rats was studied …
inhibitors (TKIs) belong to the oral targeted therapy that gained much interest in oncology
practice, among which are erlotinib (ERL) and lapatinib (LAP). Since green tea polyphenols
(GTP) are known to be inhibitors of receptor tyrosine kinases, GTE could likely potentiate the
anticancer effect of TKIs, but with a possibility of pharmacokinetic (PK) interaction with co-
administered TKIs. In this study, the effect of GTE on the PK of ERL/LAP in rats was studied …
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