Ultrastructural analogies between intimal alterations in veins from diabetic patients and animals with STZ-induced diabetes

B Mompeõ, F Ortega, L Sarmiento, I Castaño - Annals of vascular surgery, 1999 - Elsevier
The aim of this study was to document similarities and differences between veins from
human diabetic patients and an experimentally induced diabetic animal model. The
sapheneous vein and posterior tibial vein from diabetic patients and the femoral vein from
rats were studied. An increase in the extracellular matrix with migration of smooth muscle
cells and endothelial alterations were observed in the intima of all specimens. These
findings demonstrate that there is a high degree of similarity between the pathological …
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