Spiral computed tomography (SCT) is the most accessible and informative imaging method. Medical specialists face a number of difficulties with searching of CT-images. The goal of our study was to optimize interpretation of the data of radiological methods used for assessment of the paranasal sinuses (PNSs) with estimation of measurement uncertainty. The results of this study allow us to objectively assess the condition of the bone tissue and increase the efficiency of SCT examination of the PNSs, obtained taking into account both the minimum and maximum bone thickness, giving a possibility to predict the course of pathological processes in the PNSs, depending on their anatomical features. After studies, data were obtained to optimize the assessment of morphological parameters of the bone tissue of the paranasal sinuses (bone thickness and density). Potential fluctuations have been identified that should be considered when interpreting the results of calculating indices of PNS bone thickness and density.