This work is dedicated to the understanding of the basic processes involved in the formation of copper enriched clusters in low alloyed FeCu binary system (FeCu0.1wt%) under irradiation at temperature close to 300°C. Such an alloy was irradiated with electrons or with ions (Fe⁺ or He⁺) in order to deconvolute the effect of displacement cascades and the associated generation of point defect clusters (ion irradiations), and the super-saturation of mono-vacancies and self-interstitial atoms (electron irradiation). The microstructure of this alloy was characterised by tomographic atom probe. Experimental results were compared with results obtained with cluster dynamic model giving an estimation of the evolution of point defects (free or agglomerated) under irradiation on the one hand and describing homogeneous enhanced precipitation of copper on the other hand. The comparison between the results obtained on the different irradiation conditions and the model suggests that the point defect clusters (dislocation loops and/or nano-voids) created in displacement cascades play a major role in copper clustering in low copper alloy irradiated at 573K.