Understanding the chemistry and biology of glycosylation with glycan synthesis

L Krasnova, CH Wong - Annual review of biochemistry, 2016 - annualreviews.org
Glycoscience research has been significantly impeded by the complex compositions of the
glycans present in biological molecules and the lack of convenient tools suitable for studying
the glycosylation process and its function. Polysaccharides and glycoconjugates are not
encoded directly by genes; instead, their biosynthesis relies on the differential expression of
carbohydrate enzymes, resulting in heterogeneous mixtures of glycoforms, each with a
distinct physiological activity. Access to well-defined structures is required for functional …
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