Understanding the enzymology of archaeal DNA replication: progress in form and function
SA MacNeill - Molecular Microbiology, 2001 - Wiley Online Library
Molecular Microbiology, 2001•Wiley Online Library
The analysis of completed archaeal genome sequences led to the identification of a set of
approximately 10–20 genes whose protein products were inferred to be involved in
chromosomal DNA replication. Until recently, however, little was known of the biochemical
properties of these proteins. Here, I review recent progress in this area brought about by
biochemical and structural analysis. Aside from shedding considerable new light on the
molecular machinery of DNA replication in the archaea, the results of these studies also …
approximately 10–20 genes whose protein products were inferred to be involved in
chromosomal DNA replication. Until recently, however, little was known of the biochemical
properties of these proteins. Here, I review recent progress in this area brought about by
biochemical and structural analysis. Aside from shedding considerable new light on the
molecular machinery of DNA replication in the archaea, the results of these studies also …
The analysis of completed archaeal genome sequences led to the identification of a set of approximately 10–20 genes whose protein products were inferred to be involved in chromosomal DNA replication. Until recently, however, little was known of the biochemical properties of these proteins. Here, I review recent progress in this area brought about by biochemical and structural analysis. Aside from shedding considerable new light on the molecular machinery of DNA replication in the archaea, the results of these studies also present new opportunities for understanding the molecular events of chromosomal DNA replication in eukaryotic cells.
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