… aims of this study were to determine the effects of heparin on … Secondary objectives were to
estimate the effects of heparin … subgroups defined by site of infection and baseline values of …

… human research, and the understanding of the molecular biology regarding inflammation
and coagulation, supports a randomized clinical trial for the use of heparin in sepsis. Our study …

… We included Randomized controlled trials (RCTs) and the main outcome was 28 d mortality.
Data analysis was … In this study, we demonstrated that UFH was an effective treatment for …

… However, the participants enrolled in the HETRASE study suffered from less severe sepsis
… Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study…

… Patients were eligible for this study if they had a known or suspected infection and if they met
the following criteria: … In conclusion, HETRASE was the first trial testing the hypothesis that …

… unfractionated heparin (UFH) for sepsis in this your journal (1). This first large randomized,
doubleblind, placebo-controlled clinical trial … A prospective, randomized clinical trial. J Trauma …

… Randomized controlled trials (RCTs) have not definitively … and observational studies have
suggested their effectiveness in sepsis … Unfractionated heparin, widely used around the globe, …

… therapy, either alone or in combination with the intended study drug(26). A recently completed
systematic review of all human randomised controlled trials of heparin demonstrated a …

… validate their clinical utility by large randomized controlled trials (… , single-center clinical trial
(the HETRASE Study) in 2009 to … Unfractioned heparin for treatment of sepsis: A randomized …

… the Index Medicus of randomized clinical trials (RCTs), meta-… study of multicenter, randomized
placebo-controlled studies … unfractionated heparin and low-molecular-weight heparin. …