Unprecedented dinuclear silver (I)-mediated base pair involving the DNA lesion 1, N 6-ethenoadenine
The DNA lesion 1, N6-ethenoadenine (εA) has been investigated with respect to its metal-
binding properties. A synthetic DNA duplex comprising an εA: εA mispair readily forms
doubly silver (I)-mediated base pairs εA–Ag (I) 2–εA, representing the first example for a
dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first
example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.
binding properties. A synthetic DNA duplex comprising an εA: εA mispair readily forms
doubly silver (I)-mediated base pairs εA–Ag (I) 2–εA, representing the first example for a
dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first
example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.
The DNA lesion 1,N6-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA : εA mispair readily forms doubly silver(I)-mediated base pairs εA–Ag(I)2–εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.
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