Unraveling melanin biosynthesis and signaling networks in Cryptococcus neoformans
D Lee, EH Jang, M Lee, SW Kim, Y Lee, KT Lee… - MBio, 2019 - Am Soc Microbiol
Melanin is an antioxidant polyphenol pigment required for the pathogenicity of many fungal
pathogens, but comprehensive regulatory mechanisms remain unidentified. In this study, we
systematically analyzed melanin-regulating signaling pathways in Cryptococcus
neoformans and identified four melanin-regulating core transcription factors (TFs), Bzp4,
Usv101, Mbs1, and Hob1, required for induction of the laccase gene (LAC1). Bzp4, Usv101,
and Mbs1 independently regulate LAC1 induction, whereas Hob1 controls Bzp4 and …
pathogens, but comprehensive regulatory mechanisms remain unidentified. In this study, we
systematically analyzed melanin-regulating signaling pathways in Cryptococcus
neoformans and identified four melanin-regulating core transcription factors (TFs), Bzp4,
Usv101, Mbs1, and Hob1, required for induction of the laccase gene (LAC1). Bzp4, Usv101,
and Mbs1 independently regulate LAC1 induction, whereas Hob1 controls Bzp4 and …
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