… Untangling the ErbB signalling network[J]. Nat Rev Mol Cell Biol, 2001, 2(2):127r137. [4]
Normanno N,Bianco C,De Luca A,et al. Targetrbased ar gents anainst ErbB receptors and their …

… factor~alpha/ epidermal growth factor receptor signaling pathway[J].Mol Pharmacolꎬ 2012ꎬ
82(… Untangling the ErbB signaling network[J].Nat Rev Mol Cell Biolꎬ 2001ꎬ 2(2) :127 ~ 137. …

: 目的: 探讨siRNA 沉默人喉癌Hep-2 细胞C-erbB-2 基因对细胞增殖的影响, 及其与PI3K/Akt 信号
通路的关系. 方法: 利用siRNA 技术转染Hep-2 细胞C-erbB-2 基因, RT-PCR3 检测siRNA 转染…

… network was established by STRING database. Cytoscape 3.3.0 software was used for
network … The“medicine-components-targets-disease”network was constructed. GO function …

… NRGs可结合并激活由ErbB1-4组成的ErbB酪氨酸激酶受体家族成员, 启动多个下游信号转导
通路, 从而诱导细胞增殖、分化、凋亡、迁移和黏附 [8, 9] 。NRG1可通过自分泌或旁分泌方式激活…

… Untangling the ErbB signaling network [J]. Nat Rev Mol Cell Biol, 2001,2:127)137. [9] …
Biochemical and clinical implication of the ErbB/HER signaling network of growth factor receptors[J]…

Amphiregulin is a member of epidermal growth factor family, and is also one of the ligand of
epidermal growth factor receptor, it participates in many physiological and pathological …

… Untangling the ErbB signalling network[J]. Nat Rev Mol Cell Biol, 2001, 2(2):127r137. [4]
Normanno N,Bianco C,De Luca A,et al. Targetrbased ar gents anainst ErbB receptors and their …

: 近年来, 靶向治疗已成为晚期非小细胞肺癌(non-small cell lung cancer, NSCLC) 的标准治疗
方案, 但这种治疗方法对于那些具有表皮生长因子受体(epidermal growth factor receptor, EGFR) …

目的: 研究骨肉瘤组织中HER2 和PTEN/mTOR 的表达及其相关性, 探讨其在骨肉瘤发生发展中
的作用. 方法: 用S—P 免疫组化方法检测HER2 和PTEN/mTOR 在30 例骨肉瘤中的表达. 结果: …