Background—Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical
challenge. Mechanism-based approaches to AF therapy are sought to increase
effectiveness and to provide individualized patient care. K2P3. 1 (TASK-1 [tandem of P
domains in a weak inward-rectifying K+ channel–related acid-sensitive K+ channel-1]) 2-
pore-domain K+ (K2P) channels have been implicated in action potential regulation in
animal models. However, their role in the pathophysiology and treatment of paroxysmal and …

Background—Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical
challenge. Mechanism-based approaches to AF therapy are sought to increase
effectiveness and to provide individualized patient care. K2P3. 1 (TASK-1) two-pore-domain
K+(K2P) channels have been implicated in action potential regulation in animal models.
However, their role in the pathophysiology and treatment of paroxysmal and chronic AF
patients is unknown. Methods and Results—Right and left atrial tissue was obtained from …