Not much has been done to investigate the uptake and synergic effect of multiple classes of cyanotoxins on aquatic plants. Two aquatic plants Ludwigia adscendens and Amaranthus hybridus (biomass ranging 3.27 to 9.4 gL-1) were exposed to contaminated water for 14 days to test the synergic effects of cyanotoxins in solution on the plants. The plants were exposed to concentrations of 5.385-7.641 µg mL-1 for MC-LR; 8.905 µg mL-1 for MC-RR). L. adscendens accumulated microcystins up to a concentration of 0.04595±0.0004 ng mg-1 wet weight and A. hybridus accumulated microcystins up to a concentration of 0.0166±0.0016 ng mg-1 wet weight of plant material over the 14 days. Except in beaker experiments where the plants were exposed to artificial water dosed with crude extracts, the treatments and their respective controls did not show any significant difference in toxin removals (one-way ANOVA at p= 0.05), showing that the plants were unable to significantly remove the toxins from solution. When exposed to raw dam water, both plants were negatively affected as demonstrated by the loss in fresh wet weight. It was thus concluded that the cyanotoxins had adverse effects on aquatic plants at the concentrations used.