Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity
X Cao, L Shen, C Yan, Y Zhou, G Xiong, Y Wang, Y Liu… - Toxicology letters, 2017 - Elsevier
Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is
required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion
male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-
Dawley (SD) rats were used to establish animal models with PM 2.5 exposure concentration
of 0, 10, and 20 mg/kg. bw once a day for four weeks. Success rate of mating, sperm quality,
epididymal morphology, expressions of spermatogenesis markers, superoxide dismutases …
required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion
male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-
Dawley (SD) rats were used to establish animal models with PM 2.5 exposure concentration
of 0, 10, and 20 mg/kg. bw once a day for four weeks. Success rate of mating, sperm quality,
epididymal morphology, expressions of spermatogenesis markers, superoxide dismutases …
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