Urothelial-to-neural plasticity drives progression to small cell bladder cancer
G Yang, J Bondaruk, D Cogdell, Z Wang, S Lee… - Iscience, 2020 - cell.com
We report a comprehensive molecular analysis of 34 cases of small cell carcinoma (SCC)
and 84 cases of conventional urothelial carcinoma (UC), with The Cancer Genome Atlas
cohort of 408 conventional UC bladder cancers used as the reference. SCCs showed
mutational landscapes characterized by nearly uniform inactivation of TP53 and were
dominated by Sanger mutation signature 3 associated with loss of BRCA1/2 function. SCCs
were characterized by downregulation of luminal and basal markers and were referred to as …
and 84 cases of conventional urothelial carcinoma (UC), with The Cancer Genome Atlas
cohort of 408 conventional UC bladder cancers used as the reference. SCCs showed
mutational landscapes characterized by nearly uniform inactivation of TP53 and were
dominated by Sanger mutation signature 3 associated with loss of BRCA1/2 function. SCCs
were characterized by downregulation of luminal and basal markers and were referred to as …
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