[HTML][HTML] Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention
BMC Medical Research Methodology, 2020•Springer
Background Assessing benefits and harms of health interventions is resource-intensive and
often requires feasibility and pilot trials followed by adequately powered randomised clinical
trials. Data from feasibility and pilot trials are used to inform the design and sample size of
the adequately powered randomised clinical trials. When a randomised clinical trial is
conducted, results from feasibility and pilot trials may be disregarded in terms of benefits and
harms. Methods We describe using feasibility and pilot trial data in the Trial Sequential …
often requires feasibility and pilot trials followed by adequately powered randomised clinical
trials. Data from feasibility and pilot trials are used to inform the design and sample size of
the adequately powered randomised clinical trials. When a randomised clinical trial is
conducted, results from feasibility and pilot trials may be disregarded in terms of benefits and
harms. Methods We describe using feasibility and pilot trial data in the Trial Sequential …
Background
Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the design and sample size of the adequately powered randomised clinical trials. When a randomised clinical trial is conducted, results from feasibility and pilot trials may be disregarded in terms of benefits and harms.
Methods
We describe using feasibility and pilot trial data in the Trial Sequential Analysis software to estimate the required sample size for one or more trials investigating a behavioural smoking cessation intervention. We show how data from a new, planned trial can be combined with data from the earlier trials using trial sequential analysis methods to assess the intervention’s effects.
Results
We provide a worked example to illustrate how we successfully used the Trial Sequential Analysis software to arrive at a sensible sample size for a new randomised clinical trial and use it in the argumentation for research funds for the trial.
Conclusions
Trial Sequential Analysis can utilise data from feasibility and pilot trials as well as other trials, to estimate a sample size for one or more, similarly designed, future randomised clinical trials. As this method uses available data, estimated sample sizes may be smaller than they would have been using conventional sample size estimation methods.
Springer
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