Using zebrafish for investigating the molecular mechanisms of drug‐induced cardiotoxicity

ZZ Zakaria, FM Benslimane… - BioMed research …, 2018 - Wiley Online Library
Over the last decade, the zebrafish (Danio rerio) has emerged as a model organism for
cardiovascular research. Zebrafish have several advantages over mammalian models. For
instance, the experimental cost of using zebrafish is comparatively low; the embryos are
transparent, develop externally, and have high fecundity making them suitable for large‐
scale genetic screening. More recently, zebrafish embryos have been used for the screening
of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to …

Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

F Mraiche, SI Da'as - 2018 - qspace.qu.edu.qa
Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor
cardiovascular research. Zebrafish have several advantages over mammalian models. For
instance, the experimental cost of using zebrafish is comparatively low; the embryos are
transparent, develop externally, and have high fecundity making them suitable for large-
scale genetic screening. More recently, zebrafish embryos have been used for the screening
of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to …
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