[HTML][HTML] VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications
S Reina, V Checchetto, R Saletti, A Gupta… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Voltage-Dependent Anion selective Channels (VDAC) are pore-forming
mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized
isoform, presents a set of cysteines predicted to be exposed toward the intermembrane
space. We find that cysteines in VDAC3 can stay in different oxidation states. This was
preliminary observed when, in our experimental conditions, completely lacking any reducing
agent, VDAC3 presented a pattern of slightly different electrophoretic mobilities. This …
mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized
isoform, presents a set of cysteines predicted to be exposed toward the intermembrane
space. We find that cysteines in VDAC3 can stay in different oxidation states. This was
preliminary observed when, in our experimental conditions, completely lacking any reducing
agent, VDAC3 presented a pattern of slightly different electrophoretic mobilities. This …
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