We studied the neuroprotective effects of valproic acid (VPA), a primary mood stabilizer and
anticonvulsant, in cultured rat cerebral cortical neurons (CCNs). CCNs underwent
spontaneous cell death when their age increased in culture. As shown by mitochondrial
activity and calcein‐AM assays, treatment of CCNs with VPA starting from day 9 in vitro
markedly increased viability and prolonged the life span of the cultures. The neuroprotective
action of VPA was time‐dependent and occurred at therapeutic levels with a maximal effect …

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons
from spontaneous cell death : A role of histone deacetylase inhibition | CiNii Research …
Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons
from spontaneous cell death : A role of histone deacetylase inhibition …