Variants in oxidative stress-related genes affect the chemosensitivity through Nrf2-mediated signaling pathway in biliary tract cancer
M Zhan, H Wang, SW Xu, LH Yang, W Chen… - …, 2019 - thelancet.com
Background Oxidative stress and their effectors play critical roles in carcinogenesis and
chemoresistance. However, the role of oxidative stress-related genes variants in biliary tract
cancer (BTC) chemoresistance remains unknown. In this work, we aim to investigate
oxidative stress-dependent molecular mechanisms underlying chemoresistance, and find
potential biomarkers to predict chemotherapy response for BTC. Methods Sixty-six SNPs in
21 oxidative stress-related genes were genotyped and analyzed in 367 BTC patients …
chemoresistance. However, the role of oxidative stress-related genes variants in biliary tract
cancer (BTC) chemoresistance remains unknown. In this work, we aim to investigate
oxidative stress-dependent molecular mechanisms underlying chemoresistance, and find
potential biomarkers to predict chemotherapy response for BTC. Methods Sixty-six SNPs in
21 oxidative stress-related genes were genotyped and analyzed in 367 BTC patients …
以上显示的是最相近的搜索结果。 查看全部搜索结果