Versatile sarcosine and creatinine biosensing schemes utilizing layer-by-layer construction of carbon nanotube-chitosan composite films

MJ Pannell, EE Doll, N Labban, MB Wayu… - Journal of …, 2018 - Elsevier
Layer-by-layer composite films of carbon nanotubes (CNTs) within a chitosan matrix with
sarcosine oxidase enzyme and capped with Nafion have been developed and optimized as
a versatile 1st generation amperometric sarcosine biosensing platform that operates
successfully both as an isolated sarcosine sensor as well as a functional component within a
creatinine sensor. Accurate measurement of sarcosine in urine and creatinine in blood may
help with early diagnosis of diseases such as prostate cancer and renal failure, respectively …
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