… Using reverse-phase protein arrays to assess drugs in use or likely to enter trials, we … for
inhibitors of PD-L1 expression and identified verteporfin as a possible small-molecule inhibitor. …

… upstream of IRF1. To determine where in the STAT1 pathway verteporfin might be acting,
we performed IRF1 immunoprecipitation and found that whereas IFN-γ induced a marked …

… The autophagy-lysosome and ubiquitin-proteasome systems are … -AKT-mTOR signaling
pathway was significantly activated in … STAT1-IRF1-TRIM28 complex, 27 confirming that TRIM28 …

… level via the STAT3 signaling pathway in MIA PaCa-2 and … identified in 2020 that
verteporfin, a photosensitizer commonly … -related autophagy and disrupting the STAT1-IRF1-TRIM28-…

… levels of PD-L1 under verteporfin treatment. Verteporfin reduced the transcript and protein
levels of … of PD-L1 by targeting PD-L1 using siRNA, BRD4 inhibitors (JQ1 and ARV-825), and …

… Verteporfin, a photosensitizing agent primarily used in … through the activation of ERK/TTP
and p38/STAT3/IRF1 … -intrinsic PD-L1 pathway partially suppresses the basal autophagic flux …

… functions of PD-L1 and its potential influence on autophagy, … and activator of transcription
(JAK/STAT1) pathways, as crucial … main signaling pathway involved in the regulation of PD-L1 …

… To be specific, obstructing the PD-L1/PD-1 signalling pathway by antibodies … PD-L1 expression
via activation of the STAT1 signalling … of PD-L1 induced by verteporfin was reversed (50). …

… immune microenvironment partially through targeting CSCs via inhibition of YAP1 and …
VP inhibits PD-L1 expression through autophagy and the STA1/IRF1/TRIM28 signaling axis …

… Verteporfin inhibits PD-L1 through autophagy and the STAT1-IRF1-TRIM28 signaling axis,
exerting antitumor efficacy. Cancer Immunol Res 8:952–965, doi:10.1158/2326-6066.CIR-19-…