Objectives To compare the efficacy of oral and vaginal administration of misoprostol after a
single oral dose of 200 mg of mifepristone and to investigate whether the efficacy can be
improved and the duration of bleeding shortened by continuing oral misoprostol for one
week. Design Double blind, randomised controlled trial. Setting Fifteen gynaecological
clinics in 11 countries. Population A total of 2219 healthy pregnant women requesting
medical abortion with≤ 63 days of amenorrhoea. Methods Mifepristone 200 mg …

Objectives To compare the side effect profiles of regimens of oral and vaginal administration
of misoprostol after a single oral dose of 200 mg of mifepristone and to investigate patients'
perceptions of medical abortion. Design Double‐blind, randomised controlled trial. Setting
Fifteen gynaecological clinics in 11 countries. Population A total of 2219 healthy pregnant
women requesting medical abortion with≤ 63 days of amenorrhoea. Two thousand women
were asked about their perceptions of the method. Methods Mifepristone 200 mg orally on …