… WT1 mutations … One WT1 mutated patient additionally acquired a WT1 mutation at relapse
(Table 2, patient 4) and one of the eight WT1 wild-type patients acquired a heterozygous WT1 …

… WT1 mutations and stromal-predominant histology WT, suggesting that constitutional WT1
mutations … It also highlights the fact that constitutional WT1 mutations can occur in patients with …

… WT1 mutations are associated with leukemias, we screened childhood nonlymphoid malignancies
for WT1 mutation. … single WT1 mutation in 69 cases of ALL, we can conclude that WT1 …

… of patients with WT1 mutation in this study might … WT1 mutation, although WT1 mutation
was not a significant risk factor on 3-year OS and DFS by multivariate analyses. WT1 mutations …

… In this chapter, the role of WT1 in childhood cancer is discussed, using the key examples
Wilms’ tumor, desmoplastic small round cell of childhood, and leukemia. The role of WT1 in …

… of the WT1 gene, from 39 bp upstream of hood given the evidence for the involvement of
WT1 in … of WT1 mutations in codon, were examined for point mutations in a panel of 48 spor- …

… Mutations in the WT1 gene were anticipated to explain the genetic basis of the childhood
kidney cancer… Six years on, we review 100 reports of intragenic WT1 mutations and examine …

… We screened 298 diagnostic childhood AML samples for WT1 mutations. The patient
characteristics are shown in Table 1. Survival analysis was restricted to the patients who were …

… with WT1 mutations (n = 9) with patients without WT1 mutations (n = 119) and found that
WT1 … , 22% ± 28% for WT1-mutated patients vs 14% ± 7% for WT1 wild-type patients [P = .546]; …

… associated with childhood cancers, p53, Rb, and WT-1, regulate … of inherited cancer syndromes
involve mutations in tumor … , individuals with an inherited mutation only require one hit for …