White matter alterations in early-stage Alzheimer's disease: a tract-specific study
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019•Elsevier
Introduction Diffusion magnetic resonance imaging may allow for microscopic
characterization of white matter degeneration in early stages of Alzheimer's disease.
Methods Multishell Diffusion magnetic resonance imaging data were acquired from 100
participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild
cognitive impairment [MCI]). White matter microscopic degeneration in 27 major tracts of
interest was assessed using diffusion tensor imaging (DTI), neurite orientation dispersion …
characterization of white matter degeneration in early stages of Alzheimer's disease.
Methods Multishell Diffusion magnetic resonance imaging data were acquired from 100
participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild
cognitive impairment [MCI]). White matter microscopic degeneration in 27 major tracts of
interest was assessed using diffusion tensor imaging (DTI), neurite orientation dispersion …
Introduction
Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages of Alzheimer's disease.
Methods
Multishell Diffusion magnetic resonance imaging data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild cognitive impairment [MCI]). White matter microscopic degeneration in 27 major tracts of interest was assessed using diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging, and q-space imaging.
Results
Lower DTI fractional anisotropy and higher radial diffusivity were observed in the cingulum, thalamic radiation, and forceps major of participants with MCI. These tracts of interest also had the highest predictive power to discriminate groups. Diffusion metrics were associated with cognitive performance, particularly Rey Auditory Verbal Learning Test immediate recall, with the highest association observed in participants with MCI.
Discussion
While DTI was the most sensitive, neurite orientation dispersion and density imaging and q-space imaging complementarily characterized reduced axonal density accompanied with dispersed and less restricted white matter microstructures.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果