This paper presents different miniature wireless brain computer interfaces (BCI) enabling synchronized optogenetics and electrophysiology recording for various experimental conditions. These devices, which are entirely built using commercial off-the-shelf components, are validated in-vivo with small transgenic mice. First, a system including 32 electrophysiological recording channels and up to 32 high-power optical stimulation channels is presented. It can process 32 neuronal signals in parallel with high compression ratio using an embedded digital field-programmable gate array (FPGA) signal processor performing spike detection and data compression in-situ. Then, an advanced version featuring equivalent characteristics, but having the third of the size and the weight is presented. The design of a third system dedicated to small freely moving animals is presented. It includes 4 electrophysiological recording channels and 1 high-power optical stimulation channel. In-vivo result obtained in freely moving mice with this system are reported. This latter system performs aggressive data reduction using a resource optimized spike detector running on a low-power microcontroller unit. Finally, a multichannel optical stimulator operating within a network of up to 6 active devices is presented for enabling optogenetic behavioral experiments with several mice at once. These different wireless BCI all provide a multimodal access to brain activity through optogenetics and large-scale electrophysiology.