Background & Aims Conventional transarterial chemoembolization (cTACE) is used to treat
patients with hepatocellular carcinoma (HCC). Radioembolization is a minimally invasive
procedure that involves implantation of radioactive micron-sized particles loaded with yttrium-
90 (Y90) inside the blood vessels that supply a tumor. We performed a randomized, phase 2
study to compare the effects of cTACE and Y90 radioembolization in patients with HCC.
Methods From October 2009 through October 2015, we reviewed patients with HCC of all …

Dear Editors: We would like to congratulate the authors for the first randomized phase 2
study comparing the effects of conventional transarterial chemoembolization (cTACE) and
Y90 radioembolization (Y90) in patients with hepatocellular carcinoma (HCC). 1 This study
demonstrated that the primary endpoint, time to progression (TTP), was significantly longer
for Y90 compared with cTACE, and no difference was observed in either tumor response
rate or overall survival. We would like to highlight some points that might have biased the …