The yield strength of Allvac^® 718Plus^™ during aging is computed using integrated physical models that take into account intrinsic, grain boundary, solid solution and precipitate strengthening contributions. Precipitation strengthening of γ′ has the main effect on the final yield strength in this alloy during aging, with the coherency and anti-phase boundary effects providing the major strengthening contributions. We utilize transmission electron microscopy to obtain the unknown physical parameters entering the strengthening models and compare precipitate size and distribution with the simulation results.