ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors

R Kupp, L Ruff, S Terranova, E Nathan, S Ballereau… - Cancer discovery, 2021 - AACR
… as an aberrant transcription factor, binding and remodeling chromatin to … ZFTA on oncogenic
fusion proteins: nuclear translocation, chromatin binding, and the recruitment of chromatin

ZFTA–RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial ependymoma

A Arabzade, Y Zhao, S Varadharajan, HC Chen… - Cancer discovery, 2021 - AACR
… are enriched with PLAGL family transcription factor (TF) motifs… between zinc finger translocation
associated (ZFTA; formerly … represent a novel set of candidates relevant to ependymoma

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 …

, … , the BIOMECA (Biomarkers for Ependymomas in … - Acta Neuropathologica …, 2021 - Springer
… , RELA fusion positive” by “Supratentorial-ependymoma, … ependymomas exhibiting fusion
that implicates the C11orf95 (now called ZFTA) gene with or without the RELA gene, represent

Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion–positive supratentorial ependymomas

T Zheng, DR Ghasemi, K Okonechnikov, A Korshunov… - Cancer discovery, 2021 - AACR
… of supratentorial ependymomas comprise tumors with ZFTA–… containing alternative
translocations that shared ZFTA as a … chromatin binding and recruitment of chromatin remodeling

Molecular classification and therapeutic targets in ependymoma

T Larrew, BF Saway, SR Lowe, A Olar - Cancers, 2021 - mdpi.com
… nuclear translocation of β-catenin, an important factor in the Wnt-… (transcriptional enhancer
factor domain) transcription factors, … ST-ZFTA is the second main subgroup of ependymoma in …

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

K Okonechnikov, A Camgöz, O Chapman… - Nature …, 2023 - nature.com
… -C data obtained from ZFTA ependymoma tumors as well as … this chromatin cluster are the
homeobox transcription factors … For example, we observed inter-chromosomal translocations

Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice

V Herranz-Pérez, J Nakatani, M Ishii, T Katada… - Scientific Reports, 2022 - nature.com
translocation associated (ZFTA) and effector transcription … In more than two-thirds of
supratentorial ependymoma, which … proteins of ZFTA and RELA, an effector transcription factor of …

[HTML][HTML] Recent Advancements in Ependymoma: Challenges and Therapeutic Opportunities

KC Bertrand, P Klimo - Pediatric Neurosurgery, 2023 - karger.com
… the pathogenesis of ZFTA-fusion-driven ependymoma. It was … by ZFTA at specific PLAGL
transcription factor motifs, which … nuclear translocation and gene activation, toward initiation of …

Single-Cell Transcriptomics of a Mouse Model of ZFTA-RELA-Driven Supratentorial Ependymoma

J He - 2022 - search.proquest.com
… a translocation that resulted in a fusion between the ZFTA (… Transcriptional targets of
activating transcription factor 4 (Atf4… expressed in ZFTA-RELA cells and may represent novel …

Identifying the Cell Composition and Clonal Diversity of Supratentorial Ependymoma Using Single Cell RNA-Sequencing

J He - 2021 - digitalcommons.lib.uconn.edu
… It may be possible that chromatin remodeling by ZFTARELA disrupts normal lineage …
ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors