ZnO nanoparticles modified with an amphipathic peptide show improved photoprotection in skin
ZnO nanoparticles of different sizes were functionalized with an amphipathic peptide, and its
effect on nanoparticle stabilization and UV photoprotective activity was studied in this article.
The peptide-modified nanoparticles exhibited lower aggregation, significant reduction in
Zn2+ leaching in vitro and even inside the cells for smaller particle sizes, reduced
photocatalytic activity, and reduced cellular toxicity under UV-B treated conditions. In
addition, the peptide-modified 60 nm ZnO nanoparticles showed lower genotoxicity, lower …
effect on nanoparticle stabilization and UV photoprotective activity was studied in this article.
The peptide-modified nanoparticles exhibited lower aggregation, significant reduction in
Zn2+ leaching in vitro and even inside the cells for smaller particle sizes, reduced
photocatalytic activity, and reduced cellular toxicity under UV-B treated conditions. In
addition, the peptide-modified 60 nm ZnO nanoparticles showed lower genotoxicity, lower …
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